Advertising
In recent years, Ketamin starred among the experimental crowd of the well, and its image was transformed by the drug for the potential treatment of mental health and prolonged pain.
The anesthetic for a long time was used to suppress people for surgery and as an anesthetic in emergency situations. More recently, scientists also investigated it as the treatment of chronic pain and depression, with ketamine clinics appear throughout Europe.
Nevertheless, a new major study showed that there is no evidence that Keetamine really works to relieve chronic pain.
However, ketamine may be accompanied by a bunch of side effects, especially when introduced through veins. These include hallucinations, delusions, paranoia, nausea and vomiting, according to an analysis conducted by a cockery, a significant non -core research group.
Researchers came to the conclusion that the existing database is too bad to draw safe conclusions about whether ketamine can help patients suffering from chronic pain.
“We want to be clear – we are not saying that ketamine is ineffective, but there is great uncertainty.” Michael Ferraro, one of the authors of the review and researcher of the University of the New South Wales (UNSW).
“Data may indicate the benefit or have no effect. At the moment, we simply do not know “He added.
The Ferraro team analyzed the data of 67 clinical trials involving more than 2300 people. They appreciated five drugs aimed at the N-methyl-D-Sasartat receptor (NMDA), which affects how people experience pain.
It is believed that drugs known as competitors of the NMDA receptor reduce pain, blocking some brain signals. The review included ketamine, memantine, dextrometerfin, Amandadin and Magnesium.
The study studied multiple dosage strategies and the health situation of chronic pain, such as diabetic nervous pain, multiple sclerosis, fibromyalgia and complex regional pain.
According to Ferraro, while there were no clear evidence of the advantages of ketamine or other drugs, the side effects of ketamine were “painful for many patients”.
It is worth noting that there were no tests who studied how well Ketamin worked for patients with depression or as a replacement of opioid painkillers, according to the review.
Researchers warned doctors from a ketamine prescription in patients with chronic pain, based on the fact that the drug can help people who need short -term care, for example, intensive care.
“We saw damage that can lead to the taking of drugs developed for acute pain and their use to chronic pain, opioids are a typical example. Now we see a similar scheme with ketamine “James Macauley said, one of the authors of the review and the professor of UNSW.
“We must be careful not to rush with wide use without convincing evidence.”He added.