Oncoossa indicates that this study included 136 men, including 66 with a certain prostate cancer and 70 intact volunteers. Scientists have studied the influence of five genes (BRCA2, HOXB13, BRCA1, Rnasel and Elac2) at the risk of the disease. It turned out that mutations in two of them – BRCA2 and HOXB13 – were the most powerful factors that stimulate the disease.
According to the researchers, the most noticeable effect was the BRCA2 mutation, which increased the risk of prostate cancer by more than ten times. HOGB13 mutations were more dangerous, but they were less common. The rest of the studied genes (BRCA1, Rnasel and Elac2) do not have a connection with the disease.
Researchers note that these results make the way to determine more accurate people at risk, especially those who have a family history of cancer. It was previously proved that the defective BRCA2 gene causes breast cancer.
It is reported that prostate cancer is usually diagnosed with a qualitative test for prostate antigen (PSA) and biopsy (biological tissue samples for analysis). However, these methods often give improper positive results that require annoying procedures.
The study confirmed the effectiveness of another inexpensive diagnostic method, PCR-RFLP. Which allows you to determine specific mutations in DNA, using the serial polymerase reaction and analyze the length of the parts of the “cutting” of the gene by enzymes. It turns out that this method is comparable with the accuracy of the next generation sequence technology (NGS).
Source: Gazeta.ru
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